From the 5 Fwy South:

Exit El Toro Road, left on El Toro Road to Santa Margarita Parkway, right on Santa Margarita Parkway and right on Los Alisos Blvd

From the 5 Fwy North:

Exit Alicia Parkway, right on Alicia Parkway, left on Muirlands Blvd, right on Los Alisos Blvd